Tuesday, 3 July 2012

Dell buying Quest Software for $2.36 billion

(AP) ? In a move to branch out beyond the weakening personal computer business, Dell said Monday that it's buying Quest Software for about $2.36 billion.

Dell said Quest would make it more competitive in the server, storage, networking and computing services business.

Quest helps companies manage databases and provides other corporate IT services. Quest's technology would add to its security and data protections offerings, along with other services aimed at business customers, Dell said.

With the deal, Dell, the second-largest U.S. PC maker after Hewlett-Packard Co., is trying diversify beyond the lower-margin business of making personal computers. PC sales have weakened in the last two years as consumers increasingly navigate the Internet on smartphones and tablet computers such as Apple Inc.'s hot-selling iPad.

Both Dell and HP have been buying software and technology services companies to expand beyond PCs and plumb the more fertile territory of advising big companies and government agencies on how to manage their technology needs. As part of that process, the companies hope to sell more software and computing equipment.

In late May, Dell Inc. reported disappointing first-quarter financial results and predicted weak sales in the current quarter. The computer maker said sales to government, big businesses and consumers decreased. Total product revenue fell 5 percent to $11.42 billion in the Jan.-March quarter as revenue from mobility products, software, desktop PCs, and storage products all decreased. Sales to consumers took a particularly sharp decline of 12 percent, while government sales to fell 4 percent and revenue from large businesses dipped 3 percent.

Sales to small and medium-sized businesses were a bright spot. They grew 4 percent.

Dell's acquisition comes in the midst of some belt-tightening at the company. In June, it outlined a cost-cutting plan designed to trim expenses by $2 billion over the next three years.

Quest, based in Aliso Viejo, Calif., had agreed to be bought by Insight Venture Partners for $23 per share, or $2 billion, in March, and a series of increasing bids from Insight and another bidder followed.

The March bid was a 19 percent premium to the company's closing stock price the day before the deal was announced. Dell's $28 per share offer announced Monday is a 44 percent premium to Quest's ending price of $19.40 from March 8.

The deal is expected to close in Dell's August-October quarter. Both boards have approved the deal, but Quest shareholders must still vote it through.

Quest CEO Vinny Smith, who has a 34 percent stake in Quest, had agreed to support Insight's offer in March. But he will vote his shares for the Dell deal, Quest said Monday. In a statement Monday, Smith said that with the Dell deal, Quest's products and workforce would be the "foundation" for Dell's software business.

Quest paid a $25 million breakup fee as well as $12 million for expenses to Insight and Vector Capital, which joined Insight as a partner bidder last month.

Shares of Quest Software Inc. slipped 5 cents to $27.76 in morning trading. Shares of Dell, which is based in Round Rock, Texas, dipped 8 cents to $12.44. In the last year, Dell's stock has traded in a range between $11.68 and $18.36.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-07-02-Dell-Quest%20Software/id-f430856d7da7443da8abdb695d734ab9

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Monday, 2 July 2012

Quincy Jones brings jazz prodigies to Montreux stage

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Source: http://news.yahoo.com/quincy-jones-brings-jazz-prodigies-montreux-stage-162802440.html

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New way to grow, isolate cancer cells may add weapon against disease

ScienceDaily (July 2, 2012) ? The news a cancer patient most fears is that the disease has spread and become much more difficult to treat. A new method to isolate and grow the most dangerous cancer cells could enable new research into how cancer spreads and, ultimately, how to fight it.

University of Illinois researchers, in collaboration with scientists at the Huazhong University of Science and Technology in China, published their results in the journal Nature Materials.

"This may open the door for understanding and blocking metastatic colonization, the most devastating step in cancer progression," said Ning Wang, a professor of mechanical science and engineering who co-led the study.

The most dangerous cancer cells are the ones that can break away from the primary tumor and travel through the body to form a new tumor in another tissue, a process called metastasis. Fortunately, only a small percentage of cancer cells have the ability to become new tumors. Unfortunately, the tumor-seeding cells are the ones hardest to kill with chemotherapy -- and it only takes a lone survivor to mount a resurgence.

Cancer researchers have theorized that these elusive tumor-spreading cells may be responsible for recurrences after surgery or treatment. They are very interested in studying these cells in hopes of better understanding and ultimately combating them. However, identifying and isolating metastatic cells from a general cancer cell population is very difficult.

One hotly debated question is whether metastatic cells share characteristics of stem cells, and if so, to what extent. Some studies have found cancer cells with stem-cell markers, others have displayed stem-cell-like behavior, and yet others have suggested that cells can spontaneously switch from a primary cancer cell to a stem-cell-like cancer cell and back.

Wang's group at the U. of I. had previously found that stem cells grow better in a soft gel than on a rigid plate. They wondered if this principle would also apply to cancer-spreading cells, since they share some other qualities of stem cells. So they suspended single cells of mouse melanoma, a type of skin cancer, in soft gel made of fibrin, a fiber-like protein found throughout the body. They cultured the cells into colonies and compared them with those grown on a stiff flat surface, the traditional method used by cancer researchers.

After five days, the soft gels were riddled with spheres of soft cells, many more colonies than grew on the harder surface. In addition, the cells were softer and grew in spherical clumps -- unusual for most cancer cells, but signature characteristics of stem cells.

"Starting from single cells, by day five, you have more cells in the soft substrate proliferating," Wang said. "This is exactly the opposite from most cancer cells, which prefer a stiffer substrate. But these cells like to grow in the soft environment. Why is this important? Because they turn into tumors."

The researchers found that the cells grown in the 3-D soft fibrin were much more efficient at causing tumors in mice than cells prepared traditionally. In fact, injecting as few as 10 cells from a culture grown in a soft gel was sufficient to induce tumors in a large percentage of mice, while 10,000 cells from a traditional culture are needed to achieve results with the same incidence of cancer. This suggests that, while a traditional culture of cells has only a few capable of starting new tumors, the soft substrate method is capable of isolating these cells and promoting the growth and multiplication of these cells in culture.

The researchers then tested their soft fibrin substrate with other cancer cell lines and found that they also formed stem-cell-like colonies of highly tumorigenic cells, showing that the process is generalizable for many types of cancer. The cells grown in a soft gel even caused tumors in normal mice, called "wild-type," rather than only the immune-compromised mice typically needed for such studies.

The researchers also found that the tumor-repopulating cells express a self-renewal gene called Sox2, which is usually only expressed in stem cells and not in traditionally prepared cancer cells. When the researchers blocked the Sox2 gene, the cells started to differentiate, becoming traditional tissue-specific cancer cells.

Now, the researchers will continue exploring the molecular mechanisms that make these tumor-seeding cells so good at surviving in distant organs and so efficient at seeding tumors. They hope that knowledge will contribute to treatments to stop the spread of cancer.

"Since these cells are more resistant to current cancer-killing drugs than differentiated cancer cells, we would like to see if there are ways to identify and develop new molecules and methods that can specifically target and kill these cells," Wang said.

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Story Source:

The above story is reprinted from materials provided by University of Illinois at Urbana-Champaign.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jing Liu, Youhua Tan, Huafeng Zhang, Yi Zhang, Pingwei Xu, Junwei Chen, Yeh-Chuin Poh, Ke Tang, Ning Wang, Bo Huang. Soft fibrin gels promote selection and growth of tumorigenic cells. Nature Materials, 2012; DOI: 10.1038/nmat3361

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120702184025.htm

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Contest winners: iQuick Tweet for iPhone and iTunes gift cards!

If there's one thing iMore loves even more than iPhones and iPads, it's giving cool iPhone and iPad accessories and apps to our awesome readers. This week we have... $15

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/WEMlh6L9L2s/story01.htm

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American mauled by chimps has 6-hours surgery

By NBC News' Rohit Kachroo and The Associated Press

NBC News

Andrew F. Oberle was attacked by chimpanzees at an animal sanctuary in South Africa.

A U.S. graduate student who was attacked by two chimpanzees while leading a tour at a sanctuary for abused animals underwent six hours of surgery on Sunday at a hospital in South Africa.

Andrew Oberle, 26, suffered extensive soft-tissue injuries to his arms and legs. His wounds were cleaned and stitched under induced sedation, said officials at Mediclinic Nelspruit hospital in Nelspruit, a city east of Johannesburg. He remained in critical but stable condition.


Oberle, a University of Texas at San Antonio graduate student, was mauled Thursday by two large male chimpanzees?who pulled him?under a fence into their enclosure at the Jane Goodall Institute Chimpanzee Eden near Nelspruit.

Oberle's sister, Elizabeth Sosa, told the St. Louis Post-Dispatch that Oberle, who grew up in St. Louis, lost his ears, his left arm and all his toes in the attack.

Chimp Eden, a joint venture with the ape conservation institute founded by renowned U.S. primatologist Jane Goodall, is a sanctuary for ill-treated chimpanzees rescued from the illegal pet and bush meat trades and from the entertainment industry.

NBC's Michelle Franzen reports.

Sanctuary director David Oosthuizen said Oberle was?working on?a master?s degree in anthropology and primatology and was inspired by Goodall to study chimps. He was working as a guide and was with a group of tourists at an enclosure holding adult male chimpanzees when he was attacked by two of the larger males, named Nikki and Amadeus.

At a press conference Sunday, Eugene Cussons, managing director of the chimp sanctuary and host of the Animal Planet show "Escape to Chimp Eden," said the animals became aggressive when Oberle tried to retrieve a rock from within their enclosure, according to NBC News.

Witnesses?reported seeing?Oberle climb over an outer fence into a ?no go zone? and step onto a rock jammed against the mesh of an inner fence, apparently so the chimp couldn?t take it and use it as a projectile, Cussons said. That?s when one chimp reached under the fence, grabbed Oberle?s foot and dragged him about 100 feet, Cussons said.

Oberle struggled, was repeatedly bitten?and became partially lodged underneath the fence.

The two chimps then turned on a vehicle that included sanctuary staff. They decided they couldn't get out to retrieve Andrew, so they retreated to a safe zone and prepared darting equipment.

NBC's Duncan Golestani reports on a chimpanzee attack in South Africa that left a researcher from Texas in critical condition.

Cussons said he got out of the vehicle with a handgun and fired two rounds toward the chimps. The gunfire did nothing so Cussons retreated back to the vehicle.

One chimp then jumped onto the vehicle and broke the windshield. Cussons said he fired one round through the window, striking Nikki. The wounded chimp made "vocalizations of submission and anxiety" and walked away, Cussons said.

Cussons then found the injured Oberle, with deep lacerations and extensive damage to his hands and feet. An ambulance arrived and took him away.

It was the first such attack since Cussons, working with Goodall's renowned international institute, converted part of his family's game farm into the sanctuary in 2006.

?You can train for it, you can do your best to prepare," Cussons told The Associated Press. "But when it actually happens, it's shocking and traumatic for everyone."

Cussons said it was the first time he had asked Oberle to speak to visitors. The student had arrived last month for a follow-up visit after an extended stay to observe the chimps a year or so ago, Cussons said. As a researcher, Cussons said Oberle had been trained to ensure he understood how the animals might behave and knew to keep a safe distance. Cussons said Oberle was given additional training before addressing the tour group.

Cussons said Oberle broke the rules by going through the first of two fences that separate humans from the chimps. The chimps then grabbed him and pulled him under the second fence, which is electrified. Cussons said it was unclear why Oberle had moved so dangerously close.

Oberle's mother, Mary Flint, said Friday that her son knew the risks of working with chimps and would not want them blamed for the attack.

"He adored them," she said. "Since he was a little boy he just loved them, and I just have faith that ... when all is said and done, he's going to go right back into it."

The sanctuary remained closed Sunday.

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? 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://worldnews.msnbc.msn.com/_news/2012/07/01/12509158-texas-graduate-student-attacked-by-chimps-at-goodall-sanctuary-in-south-africa-undergoes-6-hours-of-surgery?lite

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Pakistan: US drone strike kills 8 militants

(AP) ? Pakistani intelligence officials say a U.S. drone strike has killed eight suspected militants in the North Waziristan tribal region near the Afghan border.

They say missiles fired from an unmanned drone struck a house in Dre Nishter village early Sunday. They spoke on condition of anonymity because they were not authorized to talk to the media.

The officials said the house was being used by militants loyal to commander Hafiz Gul Bahadur, and some foreigners were also among the dead.

The U.S. has criticized Pakistan for failing to crack down on fighters who stage attacks in Afghanistan and has stepped up drone attacks in the tribal region to combat them.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-07-01-AS-Pakistan/id-946f28bba58c46d7b88832a34db08b5c

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Sunday, 1 July 2012

College Sophomore D?Agostino is a 5K Runner on the Rise

Imagine for a moment that you?re sprinting the last 50 meters of the 5,000 meter run, and you know you?re seconds away from catching the runner in front of you?taking you from fourth place to third, which will earn you a spot on the U.S. Olympic Team. Now imagine that a runner you had passed only meters ago suddenly sprints past you and the runner in front of you?making you the fifth place finisher in the Women?s 5,000 meter Final at the U.S. Olympic Trials at Hayward Field. This was the experience of Abbey D?Agostino on Thursday night.

Running unattached, D?Agostino is a sophomore at Dartmouth College, and by all accounts a 5K runner on the rise. In her 2010-2011 freshman year, she missed the Cross Country season due to injury, and came back to have one of the best freshman seasons in the history of Dartmouth Track & Field. She finished third in the 5K at the NCAA Championships and set the Big Green and Ivy record of 15:40.69. This performance earned her a spot on the USTFCCCA All-America team. ?I?ve had such a great year, it?s not fair to be upset,? D?Agostino said of her disappointment at not making the U.S. Olympic Team.

Though her disappointment was clear from the tears in her eyes and the cracks in her voice, D?Agostino is happy for the three women who will go on to compete in London: ?I?m glad these three women will be representing the U.S. It?ll be really fun to see them race in London.?

With a time of 15:19.98, D?Agostino?s fifth place finish was only .15 seconds behind Julia Lucas? fourth place finish of 15:19.83, and .19 seconds behind Conley?s outta-nowhere 15:19.79 third place finish.

Upon entering the final round of the 5K, D?Agostino had the fastest time out of the 16 finalists. Though the athletes were running to qualify for the finals and not necessarily to turn in record performances, D?Agostino?s ranking makes her athletic intentions clear: she came her to compete. ?I?m still young and I?ve learned so much about the sport from my experiences here. I believe every experience translates into improvement. I plan to be here in 2016.?

Contributed by Amber James

Source: http://www.usatf.org/News/College-Sophomore-D-Agostino-is-a-5K-Runner-on-the.aspx?feed=news

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